Posts Tagged ‘How to Change Medicine’



Drug Development Gets Even More Personal, Precise and Tailored

March 27th, 2012
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As we’ve discussed, Eric Topol’s “How to Change Medicine” provides valuable insights on how tailoring treatments in the clinic could boost health care effectiveness and lower costs. But we at Popper and Company would like to see industry take an additional step by using the techniques Dr. Topol recommends for patient care to develop drugs more efficiently.
 
The technology Topol recommends to stratify patients could also streamline drug development. In fact, the FDA is suggesting that faster approvals of antibiotics could result from smaller clinical trials that test antibiotics targeted against drug-resistant bacteria.
 
We now know enough about molecular biology that we can apply genomics/proteomics/metabolomics to drug development (DNA screening, identifying and validating surrogate markers, or characterizing tumors by genetic makeup). However, tailored treatments can run into challenges, including  heterogeneity in tumor cells as recently described in the New England Journal of Medicine, that resist even targeted biological treatments.
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Eric Topol’s 9 Steps Toward Better Health Care—We Add a 10th

March 8th, 2012
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There appear to be a growing number of revolutions in health care and the life sciences industry. Whether you’re considering the genomics revolution, the information revolution, or the empowered patient revolution, a strong need to “fix” our health care system – to address the various inefficiencies that cause costs to increase and that put quality of care at risk – seems to be at the root of these movements.
 
Dr. Eric Topol, a cardiologist and scientist at the Scripps Research Institute, recently published a short article on “How to Change Medicine.” The article, which is excerpted from Dr. Topol’s book, The Creative Destruction of Medicine, provides nine key steps to changing health care delivery: from changing focus from populations to individual patients, to using genomic data to help “fit” treatments for each patient, to redesigning the way doctors are reimbursed.
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